Age related Macular Degeneration (AMD) is the leading cause of irreversible blindness in the elderly. The aim of\r\nthe present study is therefore to explore the relationship between the presence of multiple gene polymorphisms and\r\ntwo distinct advanced ââ?¬Å?dry and wetââ?¬Â phenotypes of AMD, and also to assess gene interactions with the influence of\r\npersonal factors.\r\nSeventy three unrelated participants grouped as 29 wet and 26 dry type AMD patients, and 18 healthy controls.\r\nThey were all genotyped for the multiple gene polymorphisms in 12 different genes. Genotyping was carried out\r\nby reverse hybridization. The data set collected was then analysed by using the Bayesian inference methods and\r\nvisualised by means of the Bayesian Networks.\r\nThe results of all the analyses suggest that (1) PAI-14G/5G and FV G1691A genes have the joint roles in the\r\nseparation of the three groups (wet, dry AMD and control group), (2) both wet and dry AMD can be separated from the\r\ncontrol group by the genes PAI-1 4G/5G, FV G1691A, FXII V34L and PT G20210A, (3) the wet AMD and control group\r\ncan be separated by the combination of the ACE I/D and B Fibrinogen-455 G-A gene polymorphisms, (4) the wet AMD\r\nand control group can be distinguished by the combination of the BMI, MTHFR-C677T and PAI-1genes, (5) there is a\r\ncorrelation between the wet AMD and high BMI (>30kg/m2), (6) the impact of BMI on the disease development seems\r\nonly in question with the connective availability of the genes MTHFR C677T and PAI-1.\r\nIt can be concluded that the combination of the MTHFR C677T and PAI-1 4G/5G gene polymorphisms in the\r\npresence of obesity may increase the risk of wet AMD type. In addition, the results further support a complex interplays\r\namong genetic and environmental factors in the development of different phenotypes
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